Summary
Chronic kidney disease (CKD) is a condition where the kidneys lose their ability to function properly over time. It often goes unnoticed until it reaches advanced stages, making early detection crucial. CKD is usually identified through laboratory tests, including markers like protein in the urine (proteinuria), blood in the urine (haematuria), and a reduced glomerular filtration rate (GFR) lasting for more than 3 months.
The most common causes of CKD are diabetes and high blood pressure (hypertension). Both conditions can damage the kidneys over time.
Managing diabetes through glycemic control and maintaining healthy blood pressure are essential in slowing the progression of CKD. Additionally, medications such as renin-angiotensin system blockers and sodium-glucose co-transporter-2 (SGLT2) inhibitors can help protect kidney function, independent of blood pressure and glucose levels.
CKD also increases the risk of developing heart disease, regardless of other conditions like diabetes or high cholesterol.
Diagnosis and When to Seek Help
CKD can only be diagnosed through blood and urine tests that check for:
- Protein in the urine (proteinuria)
- Blood in the urine (haematuria)
- A reduced glomerular filtration rate (GFR), which indicates how well the kidneys are filtering blood
You should consult a healthcare provider if your child experiences:
- Swelling in the face, legs, or abdomen
- Unexplained fatigue or difficulty concentrating
- Urinary changes, such as darker or foamy urine
- High blood pressure
Management
- Control blood sugar and blood pressure: For children with diabetes or hypertension, managing these conditions can slow CKD progression.
- Medications: Drugs that block the renin-angiotensin system and SGLT2 inhibitors may be prescribed to help preserve kidney function.
- Monitor kidney function: Regular testing to track changes in kidney health and adjust treatment as necessary.
- Diet and lifestyle changes: Ensure proper hydration, a balanced diet, and regular exercise to support kidney health.
Follow-Up and Monitoring
- Ongoing kidney function assessments: Regular blood and urine tests to monitor kidney function and prevent further damage.
- Heart health checks: Since CKD increases the risk of cardiovascular disease, managing heart health is also important.
- Long-term care: Some children may need ongoing treatments or therapies to support kidney function and prevent complications.
Early diagnosis and treatment of CKD can significantly improve outcomes and prevent progression to end-stage kidney disease.
History and Exam
Key diagnostic factor
- presence of risk factors
- fatigue
- oedema
- nausea with/without vomiting
Other diagnostic factors
- arthralgia
- enlarged prostate gland
- foamy-appearing urine
- cola-coloured urine
Risk factors
- diabetes mellitus
- hypertension
- age >50 years
- childhood kidney disease
Diagnostic Investigations
1st investigations to order
- renal chemistry
- estimation of GFR
- serum cystatin C and cystatin C-based estimation of GFR
- urinalysis
Investigations to consider
- kidney biopsy
- plain abdominal radiograph
- abdominal CT
- abdominal MRI

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malformation of the kidney

disorders of sexual development

hydronephrosis

vesico-ureteral junction obstruction

vesico-ureteral reflux
